Pescadero is a census-designated place in San Mateo County, California two miles east of State Route 1 and Pescadero State Beach. The center of town, on Pescadero Creek Road, is located at latitude 37.255 and longitude 122.38028. The town is 14.4 miles south of Half Moon Bay. The ZIP Code is 94060 and the community is inside area code 650. The population was 643 at the 2010 census.